Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain
نویسندگان
چکیده
منابع مشابه
Integrated Computational Solution for Predicting Skin Sensitization Potential of Molecules
INTRODUCTION Skin sensitization forms a major toxicological endpoint for dermatology and cosmetic products. Recent ban on animal testing for cosmetics demands for alternative methods. We developed an integrated computational solution (SkinSense) that offers a robust solution and addresses the limitations of existing computational tools i.e. high false positive rate and/or limited coverage. RE...
متن کاملStudies in Sensitization to Skin
1. Techniques for the preparation of skin antigen suitable for intramuscular injection in rabbits, and of skin antigens (autolysate) for serological experiments are described. 2. A method was evolved which produced a soluble skin antigen (autolysate) suitable for performing precipitin tests. 3. Injection of the rabbit skin antigen and of staphylococcus toxin in rabbits resulted in the formation...
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EDITSHAL and usually, as in the present case, constructional apraxia will be detected with or without ideational apraxia, alexia, or sensory agnosia. Interpretation of Gerstmann's syndrome as an easily demonstrated and memorable pointer to diffuse cerebral damage accords well with this case, where there is no reason to suspect a highly focal lesion. Gerstmann's syndrome does not seem to have be...
متن کاملSafety Evaluation of Cosmetic Ingredients Regarding Their Skin Sensitization Potential
Up to today, product safety evaluation in the EU is predominantly based on data/information on their individual ingredients. Consequently, the quality and reliability of individual ingredient data is of vital interest. In this context, the knowledge about skin sensitization potential is an explicit need for both hazard and risk assessment. Proper skin sensitization data of the individual chemic...
متن کاملRed skin re-read
Although relatively rare, the symptom complex of intermittent acral warmth, pain, and erythema that defines erythromelalgia (EM) has been well documented in the medical literature for over 150 years (Graves, 1838). Despite an extended awareness of this phenomenon, the cause and underlying mechanisms have until recently been completely obscure. Part of the difficulty in understanding EM has been...
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ژورنال
عنوان ژورنال: Contact Dermatitis
سال: 2009
ISSN: 0105-1873,1600-0536
DOI: 10.1111/j.1600-0536.2008.01473.x